Most of ICD genes were overexpressed in HNSCC, including CALR, ENTPD1, NT5E, HMGB1, HSP90AA1, ATG5, BAX, CASP8, PDIA3, PIK3CA, CXCR3, IFNA1, IFNB1, IL10, TNF, CASP1, IL1B, P2RX7, LY96, MYD88, CD4, FOXP3, IFNG, IFNGR1, IL17RA, and PRF1 (Figure 1B). This evidence concerns the gene PIK3CA and head and neck squamous cell carcinoma.