In our analysis, 15 of the 34 ICD-related genes were considerably linked to the prognosis of HNSCC patients, including CALR, CXCR3, PDIA3, HSP90AA1, NT5E, ATG5, PRF1, FOXP3, IL17A, CD8A, IL10, IL6, CD8B, CD4, and ENTPD1. The gene discussed is PDIA3; the disease is head and neck squamous cell carcinoma.