Most of ICD genes were overexpressed in HNSCC, including CALR, ENTPD1, NT5E, HMGB1, HSP90AA1, ATG5, BAX, CASP8, PDIA3, PIK3CA, CXCR3, IFNA1, IFNB1, IL10, TNF, CASP1, IL1B, P2RX7, LY96, MYD88, CD4, FOXP3, IFNG, IFNGR1, IL17RA, and PRF1 (Figure 1B). Here, TNF is linked to head and neck squamous cell carcinoma.