PRF1 and head and neck squamous cell carcinoma: In our analysis, 15 of the 34 ICD-related genes were considerably linked to the prognosis of HNSCC patients, including CALR, CXCR3, PDIA3, HSP90AA1, NT5E, ATG5, PRF1, FOXP3, IL17A, CD8A, IL10, IL6, CD8B, CD4, and ENTPD1.