Most of ICD genes were overexpressed in HNSCC, including CALR, ENTPD1, NT5E, HMGB1, HSP90AA1, ATG5, BAX, CASP8, PDIA3, PIK3CA, CXCR3, IFNA1, IFNB1, IL10, TNF, CASP1, IL1B, P2RX7, LY96, MYD88, CD4, FOXP3, IFNG, IFNGR1, IL17RA, and PRF1 (Figure 1B). The gene discussed is NT5E; the disease is head and neck squamous cell carcinoma.