In our analysis, 15 of the 34 ICD-related genes were considerably linked to the prognosis of HNSCC patients, including CALR, CXCR3, PDIA3, HSP90AA1, NT5E, ATG5, PRF1, FOXP3, IL17A, CD8A, IL10, IL6, CD8B, CD4, and ENTPD1. This evidence concerns the gene NT5E and head and neck squamous cell carcinoma.