TLR7 and lupus nephritis: Here, we investigated the pathogenic role of TLR7 in NZBWF1 mice using an anti-TLR7 inhibitory mAb This mAb ameliorated lupus nephritis in NZBWF1 mice by acting on B cells and monocytes/macrophages, thereby reducing IgG deposition in glomeruli and diminishing autoantibody production.