Importantly, using publicly available scRNAseq datasets, the KLRB1 transcriptional program (genes that had significantly higher expression in KLRB1+ T cells vs. KLRB1- T cells) was identified in tumor infiltrating T cells from multiple human cancers, including melanoma, NSCLC, hepatocellular carcinoma, and colorectal cancer (CRC). This evidence concerns the gene KLRB1 and hepatocellular carcinoma.