Another phase 1 clinical trial demonstrated an overall response rate (ORR) of 27.3%, which included 2 complete responses and 4 partial responses, in 22 metastatic melanoma patients treated with CD40 agonism (selicrelumab) in combination with anti-CTLA4 (tremilimumab) (NCT01103635). This evidence concerns the gene CTLA4 and metastatic melanoma.