CD27 and discoid lupus erythematosus: While an increase in CD45+ immune cells was observed in the skin of patents with CLE, we observed the highest infiltration of CD20+ B cells and CD27+ mature B cells in DLE lesional skin, followed by ACLE lesions, and SCLE lesional skin harbored the lowest infiltration of these immune cells among these CLE subtypes (Figure 6 and Supplementary Figure 4).