TF and COVID-19: A C-linked release of TF has been observed in COVID-19, mainly due to a direct virus-dependent effect on ECs, in which viral infection of the endothelium provokes release of viral proteins able to activate C with consequent stimulation of TF production by neutrophils, monocytes and ECs, as well as causes endothelial injury that would expose subendothelial TF (66, 67, 95, 96).