A C-linked release of TF has been observed in COVID-19, mainly due to a direct virus-dependent effect on ECs, in which viral infection of the endothelium provokes release of viral proteins able to activate C with consequent stimulation of TF production by neutrophils, monocytes and ECs, as well as causes endothelial injury that would expose subendothelial TF (66, 67, 95, 96). This evidence concerns the gene TF and viral infectious disease.