As IFNλs can also signal in other tissues apart from the human liver (8, 21), and there is an emerging role for IFNλ4 in extra-hepatic environments, we assayed whether human colon carcinoma cells (T84) were capable of inducing pSTAT1 in response to IFNλ4 and its variants. The gene discussed is IFNL4; the disease is colon carcinoma.