Numbers of Th17 cells that make IL-17 are lower than Th1 and Th2 cells but still higher than in normal controls (138) while Tregs that make IL-10 and TGF-β are increased in the blood and lymph nodes of CLL patients (139) and correlate directly with more aggressive disease (140). The gene discussed is IL10; the disease is B-cell chronic lymphocytic leukemia.