Moreover, high OGT expression in primary cells is associated with an adverse clinical outcome in DLCL and MM as well as CLL (Figure 3A), although a complete picture of the role of O-GlcNAcylation requires information on OGT and OGA protein expression along with a catalogue of the cancer specific O-GlcNAcome. This evidence concerns the gene OGA and B-cell chronic lymphocytic leukemia.