Among them, RLRs consisting of RIG-I (retinoic acid-inducible gene I), MDA5 (melanoma differentiation associated factor 5) and LGP2 (laboratory of genetics and physiology 2) are key sensors for virus infection, which mediate the transcriptional induction of type I interferons (IFNs) and interferon-stimulated genes (ISGs) to establish an antiviral immune response (4). Here, RIGI is linked to viral infectious disease.