TNFRSF4 and neoplasm: While the stark difference observed here in the potent anti-tumor activity of CpG+OX40 in A20 tumors (~350 mm3) compared to the absence of any effect in B78 tumors (~150 mm3) might reflect the difference in responsiveness of “hot” vs. “cold” tumors, CpG+OX40 may induce some anti-tumor effects against much smaller B78 tumors.