Acute GvHD: Monlish and colleagues recently identified that alloreactive donor T-cells selectively increase AMPK activation during aGvHD after allo-HCT as they found elevated phosphorylation of AMPKα and the downstream molecule ACC in CD4+ and CD8+ T-cells isolated from mice on day 7 after allo-HCT (175). The gene discussed is CD4; the disease is graft versus host disease.