Furthermore, it has been shown, in an atherosclerosis model using ovariectomized female mice, that E2 treatment decreased the expression of NADPH oxidase and the superoxide anion formation, while it increased the expression of two ROS-scavenging enzymes (Cu/ZnSOD and MnSOD), which suppose the E2 anti-oxidative effect (46). Here, SOD2 is linked to atherosclerosis.