In this regard, exosomes from HT patients cocultured with peripheral blood mononuclear cells (PBMCs) of healthy humans increased the percentage of CD4+ IFN-γ+ Th1 cells and CD4+IL-17A+ Th17A cells in PBMCs, and decreased the percentage of CD4+CD25+Foxp3+ Treg cells in PBMCs (81). This evidence concerns the gene IFNG and hematocrit.