IFN-gamma induced proteins like Galectin 3 (LEG3) and Proteasome activator complex subunit 1 - PSME1), found to be upregulated in CCC myocardial tissue, may play a role in the pathology of heart failure and cardiac remodeling; with Galectin-3 showing a stimulatory effect on macrophage migration, fibroblast proliferation and development of fibrosis. The gene discussed is LGALS3; the disease is heart failure.