Therapy targeting mitochondrial function and energy imbalance should thus in principle be beneficial to restore cardiac function in CCC and other IFN-gamma-dependent inflammatory heart diseases, like viral myocarditis and inflammatory cardiomyopathy of other etiologies and age-related myocardial inflammation and functional decline (72), myocardial infarction (73) and anthracycline antitumor agent cardiotoxicity. Here, IFNG is linked to viral myocarditis.