CD4 and non-small cell lung carcinoma: For example, Guo and colleagues performed single-cell sequencing analysis of TILs within Non-Small-Cell-Lung Cancer (NSCLC) specimens, and identified several intratumoral CD4 and CD8 T cell clusters, including TRM-like cells expressing high levels of mRNA coding for CD69, for the chemokine receptor CXCR6, and for the integrins CD49a (ITGA1 gene), and CD103 (ITGAE gene) (76).