In a big transcriptomic study, in which >300 million T-cell derived mRNA transcripts were sequenced, the same expanded clonotypes of T cells were found in the tumor, in normal adjacent tissue, and in peripheral blood, thus suggesting that non-exhausted recirculating T cells from non-tumoral sites are recruited into the tumor in response to anti-PD-L1 (107). Here, CD274 is linked to neoplasm.