TGFB1 and neoplasm: Indeed, they are inhibited by a variety of immunosuppressive mechanisms in the TME, including inhibition by high levels of TGF-β and/or other cytokines, negative regulation by innate cells such as Tumor Associated Macrophages (TAM) and MDSCs, metabolic competition with tumor cells (48), and an imbalance among T cell subsets, with a Treg dominance (49).