For example, Guo and colleagues performed single-cell sequencing analysis of TILs within Non-Small-Cell-Lung Cancer (NSCLC) specimens, and identified several intratumoral CD4 and CD8 T cell clusters, including TRM-like cells expressing high levels of mRNA coding for CD69, for the chemokine receptor CXCR6, and for the integrins CD49a (ITGA1 gene), and CD103 (ITGAE gene) (76). The gene discussed is ITGA1; the disease is non-small cell lung carcinoma.