In addition to CORO1A deficiency, defects in T cell egress from the thymus have been documented in murine models defective in a number of actinopathy-related molecules: DOCK8 (112), DIAPH1 (33), STK4/MST1 (73, 74) and MSN (39, 52). The gene discussed is DOCK8; the disease is alpha-actinopathy.