Both percentages and absolute numbers of total B220+ cells, B220+IgD-IgM-CD24intCD43+ pro-B cells, B220+IgD-IgM- CD24hiCD43- pre-B and B220+IgD+IgM+ mature B cells were decreased in BM of tumor-bearing IDO deficient mice compared with naïve IDO deficient mice (Supplementary Figures 8A, B, 9A, B). The gene discussed is IDO1; the disease is neoplasm.