Immunosuppressive properties of B cells, especially the production of IL-10 in experimental autoimmune encephalomyelitis (EAE) mice model is dependent on toll-like receptor-2 (TLR-2), toll-like receptor-4 (TLR-4)and myeloid differentiation primary response 88 (MyD88) signaling (32). Here, TLR4 is linked to experimental autoimmune encephalomyelitis.