Using a syngeneic murine model of lung cancer with intravenous implant LLCs, we first studied the kinetics of infiltration of CD19+CD1dhiCD5+IL-10+ Bregs which significantly increased in a time-dependent manner (Figure 1A). We and others have previously reported that immunosuppressive MDSCs are important drivers of tumor growth in this tumor model (41, 45). Here, IL10 is linked to lung carcinoma.