The results indicated that TNFRSF10B, CD40, and TNFSF13B were risk factors for SCLC patients, while TNFRSF21, TNFRSF25, TNFRSF1B, RELT, and TNFSF14 were protective prognostic factors. This evidence concerns the gene TNFRSF21 and small cell lung carcinoma.