Thereby, this group share some striking similarities with the classic examples of the so-called Tregopathies like immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-like monogenic syndromes caused by mutations in FOXP3 (43), and other genes (CTLA-4, CD25, LRBA, STAT1, STAT3, STAT5b, BACH2) mutations, respectively (45). Here, CTLA4 is linked to polyendocrinopathy.