IL6 and acute lymphoblastic leukemia: The low antibody production and decreased cellular immunity derived from abnormal IL-6 expression detected in ALL cases (Figure 2B), in addition to the association between single-nucleotide polymorphisms in the IL-6 gene and susceptibility to ALL (the genotype of which correlated with IL-6 serum levels), are evidence of the relevance of this cytokine in this malignant disease (141, 144, 145).