Given the relevance of JAK2/STAT pathways secondary to LPS response in monocytes, and to the transcriptional regulation of tolerized genes, we compared the effect in DNA methylation of patients with sepsis caused by gram-negative bacteria in comparison with other patients with sepsis and patients with systemic inflammatory response syndrome (SIRS) following cardiac surgery, from our previous study (13). This evidence concerns the gene JAK2 and systemic inflammatory response syndrome.