Given the relevance of JAK2/STAT pathways secondary to LPS response in monocytes, and to the transcriptional regulation of tolerized genes, we compared the effect in DNA methylation of patients with sepsis caused by gram-negative bacteria in comparison with other patients with sepsis and patients with systemic inflammatory response syndrome (SIRS) following cardiac surgery, from our previous study (13). The gene discussed is SOAT1; the disease is Sepsis.