A recent study found that GSDMD-/- mice developed increased renal C3 and IgG deposition, more severe renal injury and enhanced mortality in an imiquimod-induced model of SLE.17 To clarify further the role of GSDMD in LN, MRL/lpr mice were treated with Ac-FLTD-CMK21 starting at 8-weeks-old, with vehicle as the control. This evidence concerns the gene C3 and systemic lupus erythematosus.