Moreover, increased HLA-DRLowCD141+ C. Mono, which was previously reported in ICU patients displayed equivalent changes across our active mild and severe COVID-19 (8).The third cluster was positively associated with severe COVID-19 infection showing increased CXCR5+ memory B cells in groups II/III, and many LD Neu immunotypes such as IgA+, PD-L1+ and CD5+ in ICU groups III/IV (Figures 5A–C). This evidence concerns the gene CXCR5 and COVID-19.