IGHE and allergic asthma: Previously, we reported that, compared with wild-type mice, Dock8 KO mice show increased serum IgE levels and develop significant airway inflammatory infiltration and airway hyper-responsiveness in the OVA-induced allergic asthma model 20, a finding that is consistent with the data presented above; the serum level of OVA-specific IgE in Dock8 KO mice was also increased (Figure 1H).