IFNK and systemic lupus erythematosus: The fact that KLH/ISA51-treated mice belatedly developed low titers of non-neutralizing-anti-IFNα Abs starting at day+94, and that all control mice had low counts of anti-IFNα-IgG-secreting splenocytes, indicate that, IFN-K induces an anti-IFNα Abs production by increasing or promoting the maturation of pre-existing autoreactive B cells as previously described in SLE patients (20, 43).