SPP1 mRNA expression by airway macrophages in unadjusted analysis was not associated with survival in either group and after adjustment for age, CPI and UIP pattern, SPP1 associate with better outcomes in IPF (HR 0.6; CI 0.4-0.97 p=0.04) but not in the Non-IPF group (HR 0.9, CI 0.7-1.2, p=NS). Here, SPP1 is linked to idiopathic interstitial pneumonia.