In addition, Bifidobacterium sp., which has a significant anti-CRC effect in vitro and in vivo, markedly induced apoptosis in the early phase through the downregulation of the expression of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2), both of which are related to cell proliferation (Parisa et al., 2020). Here, EGFR is linked to colorectal carcinoma.