A recent study demonstrated that the extract of Lactobacillus plantarum strain 06CC2 induced mitochondrial-mediated apoptosis through the activation of c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (p38 MAPK) signaling in CRC cells (Hiraishi et al., 2019). The gene discussed is MAPK14; the disease is colorectal carcinoma.