Resistance loci to systemic salmonellosis were mapped (Mariani et al., 2001; Wigley et al., 2002, 2006; Fife et al., 2009) and refined to an 8kb, 14 gene region on chromosome 5, termed SAL1, including the CD27-binding protein and AKT1, a REAC-alpha serine/threonine protein kinase homolog, both involved in innate immune response signaling (Kaiser et al., 2009). The gene discussed is CD27; the disease is salmonellosis.