(14) has found that the expression of the inflammasome, including the NOD-like receptor (NLR) family pyrin domain containing 3 (NLRP3), AIM2, caspase-1, and IL-1β mRNA and protein from patients with HT, was significantly increased, which can be regulated by the gut microbiota and its metabolism (15–17). This evidence concerns the gene NLRP3 and hematocrit.