Studies found a notable increase in the expression of inflammasome components, including NLRP1,NLRP3,NLRC4,and AIM2 in HT patients, which can be activated by intestinal microbiota through PAMPs (pathogen-associated molecular pattern molecules (PAMPs) or DAMPs (damage-associated molecular pattern molecules (DAMPs) patterns. The gene discussed is NLRP1; the disease is hematocrit.