Recently, we and others have found that members of the CTRP family, such as c1q/tnf related protein subtype 6 (CTRP6), CTRP5, and CTRP15, are associated with the occurrence of MetS, type 2 diabetes mellitus (T2DM), and obesity (6–12). The gene discussed is C1QTNF6; the disease is type 2 diabetes mellitus.