In the current study, we find that increased serum CTRP7 levels are significantly associated with decreased circulating APN levels in MetS patients, as well as with other MetS components such as BP, blood glucose, WC and TG, etc. Logistic regression and ROC curve analysis reveals that circulating CTRP7 is significantly related to the occurrence of MetS. This evidence concerns the gene C1QTNF7 and metabolic syndrome.