ACE2 and Hyperglycemia: Although there is no direct evidence on effects of the combination of SARS-CoV-2 and ACE2 on its signaling cascade reactions, evidence from SARS-CoV-1 infections suggests that it can down-regulate ACE2 expressions (12), which may lead to up-regulation of SGLT1, thereby, aggravating hyperglycemia (154, 155).