Studies on sympathetic nerve-mediated cardiovascular diseases have found that the expression of nNOS in the paraventricular nucleus of the hypothalamus is decreased, whereas the expression of nNOS is increased in mice with spontaneous hypertension and vascular hypertension, which suggests that the expression of nNOS depends on whether the sympathetic nerve is excited (stimulated) or not (26). The gene discussed is NOS1; the disease is Hypertension.