Several covariates, including age, sex, ethnicity, educational attainment, types of marital status, household income level, smoking status, alcohol consumption, the level of CRP, self-rated health status, walking disability, and micro- and macrovascular disorders (DM, CKD and history of CVD), were strongly associated with all-cause mortality in age- and sex-adjusted models. The gene discussed is CRP; the disease is diabetes mellitus.