In representative conventional T2DM models, such as ob/ob mice and db/db mice, renal efferent arteriosclerosis as well as glomerular lesions were observed in endothelial nitric oxide synthase (eNOS)-deficient db/db mice (34) and -ob/ob mice of the BTBR strain (35). The gene discussed is NOS3; the disease is type 2 diabetes mellitus.