Nine patients (10%) were diagnosed with mammosomatotroph adenomas, one of whom did not present with hyperprolactinemia, and 1 patient (1%) was diagnosed with a non-functional adenoma based on immunohistochemistry but was considered to have acromegaly based on preoperatively elevated IGF-1 that decreased postoperatively, combined with acromegalic features. The gene discussed is IGF1; the disease is acromegaly.