The top 10 upregulated and four downregulated candidates may participate in the genesis and progression of PAIS, including RNF2, FOXA1, TAL1, BRD4, GLI2, 5HMC, PBX3, RING1 and TALE, SUZ12, MED1, and MEF2C. The gene discussed is PBX3; the disease is partial androgen insensitivity syndrome.