SSTR5 and adenoma: Others reported PRL and/or adenoma response in prolactinomas treated with combination cabergoline and pasireotide, including in an aggressive prolactinoma strongly positive for SST5 that demonstrated PRL normalization after 2 months that was maintained for 31 months, with >50% reduction in adenoma size (65), as well as in a cabergoline-resistant giant silent prolactinoma showing high expression of SST5 that demonstrated adenoma shrinkage with pasireotide treatment (66).