One subject demonstrated near normalization of PRL and a 22% reduction in adenoma volume after showing continued adenoma growth and PRL elevation on cabergoline 7 mg/week and surgical adenoma resection; a second subject with persistent hyperprolactinemia and adenoma growth on cabergoline 7 mg/week and surgical resection achieved a 42% reduction in PRL and tumor size stabilization (85). The gene discussed is PRL; the disease is adenoma.