NEFL and Huntington disease: Plasma NfL showed remarkable diagnostic ability [AUC = 0.970, 95% CIs for AUC: 0.929–1.000, p < 0.0001] while plasma GFAP could not distinguish preHD and manifest HD (AUC = 0.659, 95% CIs for AUC: 0.496–0.822, p = 0.070; Figure 1F).