A retrospective national cohort study on antihypertensive drug use and AD risk in diabetic individuals demonstrated that the most effective treatment for lowering AD risk is seen with angiotensin II receptor blocker use (24% lower risk of dementia), followed by diuretics (14%), angiotensin-converting-enzyme inhibitors (11%) and b-blockers (4%) (79). This evidence concerns the gene ACE and Alzheimer disease.