When compared MOG-Ab+ patients with (N. 8) and without (N.7) encephalopathy (Table 2), children belonging to the first group resulted significantly younger at sampling (median and range: 4.5/2.17–11.17 vs. 14.16/9.8–17.5; p = 0.004), had higher sNfL levels (median/range: 75.24/9.1–1,129 vs. 10.22/6./6.83–50.53; p = 0.04), and showed a trend for higher MOG-Ab titers (0.28/0.04–0.69 vs. 0.05/0.04–0.28; p = 0.1) in comparison to those without encephalopathy. Here, MOG is linked to Encephalopathy.