MBDs include changes in serum calcium (Ca2+) concentration, increased serum phosphate levels (hyperphosphatemia), reduced serum levels of active vitamin D, secondary increase of parathyroid hormone (PTH), augmented FGF-23 systemic levels, and reduced levels of the antiaging factor Klotho (Wang et al., 2018). This evidence concerns the gene FGF23 and hyperphosphatemia.