ZYX and neoplasm: However, when considering that LPP, in contrast to zyxin, is highly enriched in SMC, and in particular in vascular SMC (Gorenne et al., 2003; Nelander et al., 2003; Petit et al., 2008), in both mice and humans (see above), and its established role in the proliferation and migration of tumor cells, its role in the vasculature as a modulator of the SMC phenotype under tensile stress surely deserves proper attention.