Finally, the elevated production of sFlt-1 and sEng and the decrease of VEGF and PIGF secretion induce an impairment of endothelial function, causing preeclampsia (De Oliveira et al., 2013; Shah and Khalil, 2015; Poniedziałek-Czajkowska et al., 2021). This evidence concerns the gene VEGFA and preeclampsia.