Moreover, the level of GPER1 in placentas from preeclampsia reduced by about 50%, a reduction that can partially be associated with estrogen treatment in trophoblast culture (Feng et al., 2017), which correlates with elevated apoptosis and minor cellular proliferation in the placenta from preeclampsia (Li et al., 2016). This evidence concerns the gene GPER1 and preeclampsia.