However, excessive production of IL-6 and TNF-α over a period of time causes systemic inflammation, which is eventually involved in developing metabolic diseases, including CVDs, diabetes, various cancer types, chronic kidney disease, non-alcoholic fatty liver disease (NAFLD), and neurodegenerative conditions (Furman et al., 2019). The gene discussed is IL6; the disease is metabolic dysfunction-associated steatotic liver disease.