However, in an alternative model of hypertension, the 2 kidney 2 clip model, TMEM16A expression and IClCa are reduced and CaCC activity is negatively correlated with blood pressure and medial cross-sectional area of the basilar artery (Wang et al., 2012), suggesting that downregulation of CaCC is associated with the cerebrovascular remodelling that occurs during hypertension. Here, ANO1 is linked to Hypertension.