ANO1 and hypertensive disorder: However, in an alternative model of hypertension, the 2 kidney 2 clip model, TMEM16A expression and IClCa are reduced and CaCC activity is negatively correlated with blood pressure and medial cross-sectional area of the basilar artery (Wang et al., 2012), suggesting that downregulation of CaCC is associated with the cerebrovascular remodelling that occurs during hypertension.