TGFB1 and Hepatic fibrosis: Additionally, miR-455-3p reduces liver fibrosis and HSC activation by inhibiting the expression of HSF1 (Wei et al., 2019), and miR-199a-3p exacerbates hepatic fibrosis by inhibiting the expression of caveolin-2 and triggering the TGF-β pathway (Yang et al., 2020).