Upcoming studies related to TRPV channels will likely include the channels mostly associated with ischemia and inflammation, such as those in the sensory fibers (TRPV1 and TRPV3) that modulate cardiovascular tone and potentially the preconditioning response and those in macrophages (TRPV2) that modulate the inflammatory response during and following a myocardial infarction. The gene discussed is TRPV3; the disease is myocardial infarction.