The first study to demonstrate a critical role for TRPV4 in mediating myocardial ischemia/reperfusion (I/R) injury was performed in mice with left anterior descending (LAD) coronary artery ligation, in the presence and absence of TRPV4-specific inhibitor HC067047 (Dong et al., 2017). The gene discussed is TRPV4; the disease is myocardial ischemia.