Though significant work from several labs showed increased TRPV4-dependent intracellular Ca2+ flux including increased diastolic Ca2+, prolonged Ca2+ transients, and decay times, Liao et al. were the first group to explicitly show that TRPV4 mediates atrial cardiomyocyte arrhythmogenesis and atrial fibrillation in sterile pericarditis rats (Liao et al., 2020). Here, TRPV4 is linked to atrial fibrillation.