Upcoming studies related to TRPV channels will likely include the channels mostly associated with ischemia and inflammation, such as those in the sensory fibers (TRPV1 and TRPV3) that modulate cardiovascular tone and potentially the preconditioning response and those in macrophages (TRPV2) that modulate the inflammatory response during and following a myocardial infarction. This evidence concerns the gene TRPV3 and ischemia.