TRPV4 and familial dilated cardiomyopathy: However, in addition to control hiPSC cardiomyocytes, they subjected hiPSC cardiomyocytes from DCM patients to the same stretch protocol and found stretch and TRPV4-dependent increases in intracellular Ca2+ over that seen in control hiPSC cardiomyocytes, revealing a possible role for TRPV4 in mediating myocardial pathology.