The findings of prolonged QT and APD90in vivo and in vitro suggest a possible role for TRPV4 in mediating ventricular arrhythmia similar to the previous study of TRPV4-associated arrhythmogenesis in AF by Liao et al. At around the same time, Peana et al. used sharp electrode electrophysiology in isolated perfused hearts of aged mice (+/−TRPV4 inhibition) to examine TRPV4-dependent effects on cardiomyocyte membrane potential following LAD ligation I/R (Peana et al., 2021). The gene discussed is TRPV4; the disease is Ventricular arrhythmia.