To further explore the molecular mechanism of DHM antagonizing TAA-induced liver fibrosis, western blotting and immunofluorescence staining were used to analyze the expression level of PI3K/Akt signaling pathway, including its downstream the expression levels of Bcl-2 family and caspase family proteins, which was also an important way to regulate the proliferation, apoptosis and differentiation of activated HSCs. Here, BCL2 is linked to Hepatic fibrosis.