In addition, the pharmacological experimental study has found that orally administered CHSGS to depression mice models had higher SOD and catalase CAT activities, lower malondialdehyde MDA values, and higher glutathione GSH levels compared with those of the mice in the model group, suggesting that antioxidant activity of CHSGS should make contributions to its antidepression effect (Li et al., 2010). This evidence concerns the gene CAT and major depressive disorder.