In this module, ADCYAP1R1, PRKACA, MAPK8, MAPK14, GRIA1, and FOS are both targeted genes of CGFC and pathogenic genes of depression; RHOA is a specific targeted gene of CGFC, and most of these genes are related to the pathogenesis or treatment of depression. Here, ADCYAP1R1 is linked to major depressive disorder.