GSDME and colorectal cancer: In humans, GSDME is normally expressed in the placenta, heart, brain, and kidneys; however, in mice GSDME is expressed in the cochlea, thymus, colon, lung, brain, spleen, and small intestine (Van Laer et al., 1998; Wu et al., 2009), but not in the breasts, gastric system, or colorectal cancer due to hypermethylation of its promotor (Akino et al., 2007; Kim et al., 2008; Stoll et al., 2017).