Furthermore, both GPR10 knockout mice and PrRP-deficient mice developed late-onset obesity and exhibited a significant decrease in energy expenditure compared to wild-type mice (Bjursell et al., 2007) as well as altered insulin sensitivity and lipid homeostasis (Prazienkova et al., 2021). The gene discussed is PRLH; the disease is obesity due to melanocortin 4 receptor deficiency.